Horatio the mouse is alone in the house when Dine and Dash break in to make the mouse their meal. But when Horatio accidentally eats a muscle-man energizing formula, he develops super muscles and turns the tables on the cats. Zippy wanders into an art gallery, and while shaking off his fur onto a black canvas, accidentally creates a masterpiece. His fame as an animal artist grows until Cutie Snoot, the gallery owner's cat, wants a piece of the action.

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